Constructive.bio
Life, reimagined.
Engineering the future of biology with revolutionary genome synthesis and expanded genetic code technology to scalably, flexibly, and reliably manufacture peptide therapeutics containing one or more non-canonical amino acids.
Constructive Bio Technology
Rewriting biology's source code
Redundancy
Nature's genetic code has more capacity than it uses, with 64 codons encoding only 20 building blocks.
Compression
We have rewritten the code to free up extra capacity.
Expansion
Those available slots now encode non-canonical amino acids, enabling therapeutics with properties previously impossible to produce sustainably.
Non-canonical amino acids (ncAAs) are building blocks beyond nature's standard 20, offering new chemical properties.
Expanding the capabilities of peptides and proteins
Three categories of non-canonical amino acids delivering transformative capabilities
Transformers
Enabling new functions
Unlock new functions that would be impossible with canonical amino acid chemistry alone.
- Novel reactivity
- Covalent biologics
- Non-native tertiary structures
Enhancers
Enhancing control
Deliver control where traditional chemistry falls short.
- Site-specific conjugation
- Protease resistance
- Targeted PTMs
Modulators
Tuning performance
Modulate function with precision and nuance.
- Hydrophobicity
- Solubility
- Stability
Enabling next-generation solutions
From peptides to proteins to complex assemblies
Peptides with stabilizing moieties
e.g. GLP-1 therapeutics
Enhanced stability and efficacy for metabolic disease treatment
Precise conjugation
e.g. Site-specific antibody-drug conjugates
Homogeneous products with optimal drug-antibody ratios
Covalent biologics
e.g. Proteins with reactive handles
Irreversible target engagement for prolonged effect
Modular assemblies
e.g. Immunocytokines & complex biologics
Click-chemistry enabled multi-functional therapeutics
A dual-technology revolution
Combining de-novo genome synthesis with engineered translation to create biomolecules with unprecedented precision and scale.
Three unmatched differentiators
Ultimate scalability
De-risked manufacturing at scale
Scalable biomanufacturing in E. coli and CHO. Complete backbone flexibility from milligrams to kilograms.
Unparalleled flexibility
Hundreds of exotic chemistries
Peptides and proteins of any length with multiple non-canonical amino acids in a single molecule. Hundreds of diverse chemistries with approaches to rapidly onboard new monomers.
Unprecedented reliability
Genetically encoded precision
We write entire genomes to reprogram the genetic code, ensuring every modification is exactly where specified.
Ready to reimagine biology?
Whether you're looking to partner, invest, or join our team, we'd love to hear from you.